Pyrogen Testing

A Seminar On pyrectic Testing Presented by: Luhar Shailesh V. M.Pharm-I Dept. of gauge Assurance, Maliba pharmacy college, Bardoli. Content: ? Introduction ? compartmentalization of Endotoxins ? Chemical personality and structure of the Endotoxins.

? Properties of Bacterial Endotoxins o biological Properties o corporal Properties ? Pyrogen Testing o Rabbit see (sham test) o LaL Test ? De pyrogenation Techniques o Physically removal of Pyrogens o inactivation of Pyrogens Introduction ? A Pyrogen is defined as a febrility producing agent ? Pyrogens argon products of metabolism of micro organisms. close bacterium ,viruses & many moulds have been reported as pyrogen producing. ? Pyrogen are substances that initiate febrile reactions when sufficient numbers pool enters the circulative system, therefore, the history of intravenous therapy and the history of pyrogen look for are closely related. ? The gram negative bacteria pee-pee the virtual ly potent pyrogenic substances as endotoxins! . Nature of Pyrogens: ? The termination pyrogen is frequently used to describe the pyrogen most(prenominal) real for the pharmaceutical industry, ? Endotoxins are part of the outer membrane of the cellular telephone wall of Gram-negative bacteria. Endotoxin is invariably associated with Gram-negative bacteria whether the organisms are pathogenic or not. Although the term endotoxin is on occasion used to identify to any cell-associated bacterial toxin, in bacteriology it is properly reserved to summon to the lipopolysaccharide complex associated with the outer membrane of...If you insufficiency to get a full essay, order it on our website: OrderCustomPaper.com

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